چه نسبتی از بیماران کووید 19 بدون علامت‌اند؟

Everywhere we look, we cannot get a handle on the essential facts or we get 2 completely different answers to the same question. So, we thought we would try to answer an important question: what is the proportion of people with SARS-COV-2 who are asymptomatic?

چه نسبتی از بیماران کووید 19 بدون علامت‌اند؟

Everywhere we look, we cannot get a handle on the essential facts or we get 2 completely different answers to the same question. So, we thought we would try to answer an important question: what is the proportion of people with SARS-COV-2 who are asymptomatic?

COVID-19: What proportion are asymptomatic?

Carl Heneghan, Jon Brassey, Tom Jefferson

Everywhere we look, we cannot get a handle on the essential facts or we get 2 completely different answers to the same question. So, we thought we would try to answer an important question: what is the proportion of people with SARS-COV-2 who are asymptomatic?
What did we learn (see the table for the analysis):

-That between 5% and 80% of people testing positive for SARS-CoV-2 may be asymptomatic
-That symptom-based screening will miss cases, perhaps a lot of them
-That some asymptomatic cases will become symptomatic over the next week (sometimes known as “pre-symptomatics”)
-That children and young adults can be asymptomatic

We also learnt that there is not a single reliable study to determine the number of asymptotics. It is likely we will only learn the true extent once population based antibody testing is undertaken.

 

 

Setting Proportion Comment
Diamond Princess cruise ship, Yokohama, Japan  (n=-634 tested positive). [1]

18%

(95% credible interval  16%-20%).

Most infections occurred before the quarantine start.
Vo’Euganeo, 50 km west of Venice, Italian village  [2] 50% to 75%—were asymptomatic In an open letter to the authorities in the Tuscany region
MERS-CoV [3] Increased from 0% to 29%  over time As the MERS-CoV progressed over time there was more identification of asymptomatic individuals due to increased surveillance and contacts testing.
328 adults in Shanghai [4] 13 (4%)  patients were asymptomatic
Japanese nationals evacuated from Wuhan (n=565) [5] 31% (95% CI: 7.7% to 54%) Based on  temperature screening before disembarkation, interviews on symptoms including fever, cough, and non-specific symptoms
23 Residents of a Long-Term Care Nursing Facility King County, Washington[6]

10 (43%) had symptoms, and 13 (57%) were asymptomatic.

Seven days after testing, 10 of 13 asymptomatics developed symptoms

Symptom-based screening could fail to identify approximately half of nursing home residents with COVID-19.
Airport screening of travellers [7] 17% undetectable by typical screening procedures Based on: A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: Lancet. 2020;0(0):S0140-6736(20)30154-9.  
Hospitalised in Beijing, China (n=262)[8] 13 (5.0%) asymptomatic cases
391 cases including 148 family index cases in Zhejiang Province  [9] 54 (14%)  asymptomatic higher  family  secondary attack rate, the secondary attack rate of spouses is higher than other family members.
Chinese perspective[10] Over the past few days, asymptomatic patients were found in many Chinese cities.

Whether asymptomatic people can transmit SARS‐CoV‐2 to others is unclear.

Another uncertainty is whether those who are asymptomatic can cause large‐scale infections.

36 children, Zhejiang, China [11] Asymptomatics, 10 (28%) 7 had acute upper respiratory symptoms (19%)
Data-based analysis, modelling and forecasting of the COVID-19 outbreak  [12] The number of asymptomatic and mild cases with subclinical manifestations that probably did not present to hospitals for treatment may be substantial; these cases, which possibly represent the bulk of the COVID-19 infections, remain unrecognized,
166 new infections in China  [13] four-fifths of cases are asymptomatic, China figures indicate  Numbers quoted  not verifiable
Nanjing, China (n=24) [14] 5 (21%) developed symptoms (fever, cough, fatigue and etc.) during hospitalization.
450 case reports from 93 Chinese cities. [15] estimate that people who had not yet developed symptoms transmitted around 10% of the cases they studied.
 People’s Hospital of Daofu county. Tibetan population (n=83) [16] Asymptomatic carriers 22% median age of asymptomatic carriers was 31 years and 1/3rd  were students, aged <20 years.
WHO Q&A:Similarities and differences – COVID-19 and influenza [17] suggest that 80% of infections are mild or asymptomatic,
Iceland   [18] 50% of the people who tested positive had no symptoms.” See also: First results of the voluntary screening in Iceland[19]
CDC [20] A significant number of individuals that are infected actually remain asymptomatic. That may be as many as 25%.
Interim Clinical Guidance for Management of Patients with Confirmed Coronavirus Disease [21] Among children in China, illness severity was lower with 94% having asymptomatic, mild or moderate disease,
Northern Italy, 60 volunteer blood donors [22] 40 (67%)  tested positive

 

Reference:
https://www.cebm.net/covid-19/covid-19-what-proportion-are-asymptomatic/

دستورالعمل استفاده صحیح از ماسک جهت پیشگیری از ابتلا به کرونا

دستورالعمل استفاده صحیح از ماسک جهت پیشگیری از ابتلا به کرونا

توصیه‌های عمومی در محیط کارجهت جلوگیری از ابتلا به کرونا

توصیه‌های عمومی در محیط کارجهت جلوگیری از ابتلا به کرونا

پیشگیری از ابتلا به کرونا در محیط آشپرخانه

پیشگیری از ابتلا به کرونا در محیط آشپرخانه

 توصیه‌هایی برای نگهبانان در زمان کار جهت جلوگیری از ابتلا به کرونا

 توصیه‌هایی برای نگهبانان در زمان کار جهت جلوگیری از ابتلا به کرونا

زباله‌ها را چگونه جمع آوری کنیم تا به کرونا مبتلا نشویم

زباله‌ها را چگونه جمع آوری کنیم تا به کرونا مبتلا نشویم

استاپ کرونا چیست؟!

استاپ کرونا عنوان وب سایتی است که سعی دارد تا تا با آگاه سازی هر چه بیشتر افراد مختلف جامعه، میزان گسترش ویروس کرونا، در سطح جامعه را کاهش دهد یا محدود کند.
استاپ کرونا وب سایت مرجع و علمی ویروس کرونا است. اخبار، آموزش‌ها و مقالات پیرامون ویروس کرونا را از استاپ کرونا دنبال کنید.

آغاز فاز سوم تحقیقات بالینی یک دارو در بیماران کروناویروس 2019

شرکت گیلیاد دو مطالعه فاز سوم بالینی را برای داروی تحقیقاتی ضدویروسی خود، با نام رمدسیویر (Remdesivir) در بزرگسالان مبتلا به بیماری COVID-19 شروع کرد.

تلاش یک شرکت بیوتک دیگر برای ساخت واکسن کروناویروس

رقابت برای کشف واکسن برای کروناویروس ووهان یا همان SARS-CoV2 ادامه دارد و حالا شرکت کوچک بیوتکنولوژی Novavax چهارشنبه اعلام کرد که …

در جستجوی درمان و واکسن برای بیماری کرونا 2019

در حال حاضر واکسن یا دارویی برای پیشگیری از ابتلا یا درمان COVID-19 در دسترس نیست. داروها و واکسن‌ها در فاز تحقیقاتی هستند و مجوز ورود به بازار دارویی را ندارند.

تحقیقات یک واکسن کروناویروس وارد مرحله بالینی شد

شرکت Moderna، اولین ویال واکسن کروناویروس خود، mRNA-1273 را به انیستیتوی آلرژی و بیماری‌های عفونی (NIAID) فرستاده است.

orchidpharmed
twitter
instagram
aparat

تمامی حقوق این وب سایت متعلق به شرکت زیست ارکید فارمد است | © ۱۳۹۸ . جهت برقراری ارتباط با ما می‌توانید با ایمیل [email protected] در تماس باشید.

telegram
twitter
instagram
aparat
orchidpharmed
cinnagen
stopcorona

تمامی حقوق این وب سایت
متعلق به شرکت زیست ارکید فارمد است | © ۱۳۹۸

جهت برقراری ارتباط با ما می‌توانید با ایمیل [email protected] در تماس باشید.